DNA Writing Progress Presented at GP-Write Annual Conference

Launched in 2015, Genome Project-write (GP-write) is holding its virtual conference Thursday and Friday of this week. The group, focused on writing DNA, was conceived as a continuation of the Human Genome Project. They said DNA writing is “the future of science and medicine and promises to take us forward to a better future.”

The ability to write DNA code, according to GP-write, remains limited. This, in turn, restricts the ability to understand and manipulate biological systems. GP-write, they noted, “will enable scientists to move from observation to action and facilitate the use of bioengineering to solve many global problems facing humanity.”

But the group is about more than sequencing experts. They are synthetic biologists and geneticists from all walks of life in academia and industry. They hope to make progress with the goal of drastically cutting costs and speeding up writing and redesigning the entire genome over the next decade.

Since the 2019 meeting, the launch of the GP-write technology has produced the GPW CAD, a next-generation software for the design of the entire genome of the genome of any species. This platform was published and demonstrated by Douglas Densmore, PhD, Associate Professor, Electrical and Computer Engineering, Boston University. CAD enables technology to advance genome writing capabilities and will serve as a fundamental platform in GP-write’s international foundry and incubator.

“GP-write’s technology launch now culminates with the deployment of a foundational genome design platform – a ‘one-stop-shop’ in the new GP-write international foundry and incubator for design, assembly and testing. entire genomes, ”noted Amy Cayne Schwartz, President and General Counsel of GP-write.

A researcher will soon be able to take advantage of the platform to design a genome, order synthetic DNA directly from a GPW industrial partner, and select a foundry for assembly and testing.

“This is a huge step forward for the engineering biology community and the GP-write consortium,” said Schwartz. “We are proud to partner with world leaders on our industry council as we pave the way for easier genome writing. “

GP-write has worked closely with industry partners and is expanding its reach in this area. CATALOG Technologies is the first commercially viable platform to use synthetic DNA for massive digital storage and computation. Future integration could provide a next-generation solution to store large amounts of genomic data generated on GP writing software. The company’s other partners include Agilent Technologies, Ansa Biotechnologies, Twist Bioscience, and gene editing automation companies Inscripta and Lattice Automation.

An exciting partnership with IndieBio from SOSV, the world’s leading biotech startup development program, will be announced and formalize the deployment of GP-write’s virtual foundry and startup ecosystem. Together, the GP-write and IndieBio teams will examine and select new companies that advance genome-writing capabilities, an important step towards achieving GP-write’s mission: to reduce the cost of production by 1,000 times. ‘writing and testing of whole genomes over the next decade.

According to them, reducing the cost and ease of design will be of great benefit and will provide wide accessibility. Students, citizen scientists, professionals and industry will soon be able to learn how to design genomes from scratch and receive feedback on the functional consequences of those designs. Tools for managing data within a distributed community will learn from others’ design processes through shared results.

With biosafety being a top priority, DNA Script will host a biosafety roundtable on Friday to initiate a collaborative discussion on the implications of laboratory DNA synthesis for biosafety, and the measures companies should consider when making the decision. ‘use of enabling genomic engineering technologies such as the GP-write design platform and DNA Script Printers.

Once set in motion, George Church PhD, professor of genetics at Harvard Medical School and one of GP-write’s scientific leaders, noted that GP’s genome design software, foundry, and incubator model -write “will advance the field of genomic engineering. closer to discovering complex biological behavior and designing organisms to correct genetic mutations that cause crippling diseases, reverse environmental damage and create a more sustainable future in agricultural biotechnology.

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